Detalhe da pesquisa
1.
Antiviral Properties of HIV-1 Capsid Inhibitor GSK878.
Antimicrob Agents Chemother
; 67(5): e0169422, 2023 05 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-37039636
2.
Scaffold modifications to the 4-(4,4-dimethylpiperidinyl) 2,6-dimethylpyridinyl class of HIV-1 allosteric integrase inhibitors.
Bioorg Med Chem
; 67: 116833, 2022 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35605346
3.
The Genesis and Future Prospects of Small Molecule HIV-1 Attachment Inhibitors.
Adv Exp Med Biol
; 1366: 45-64, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35412134
4.
Innovation in the discovery of the HIV-1 attachment inhibitor temsavir and its phosphonooxymethyl prodrug fostemsavir.
Med Chem Res
; 30(11): 1955-1980, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34602806
5.
A survey of core replacements in indole-based HIV-1 attachment inhibitors.
Bioorg Med Chem Lett
; 29(11): 1423-1429, 2019 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30940396
6.
Bioactivation of cyclopropyl rings by P450: an observation encountered during the optimisation of a series of hepatitis C virus NS5B inhibitors.
Xenobiotica
; 48(12): 1215-1226, 2018 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-29182424
7.
Development of the Large-Scale Synthesis of Tetrahydropyran Glycine, a Precursor to the HCV NS5A Inhibitor BMS-986097.
J Org Chem
; 82(19): 10376-10387, 2017 10 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28877441
8.
Discovery and initial optimization of alkoxyanthranilic acid derivatives as inhibitors of HCV NS5B polymerase.
Bioorg Med Chem Lett
; 27(2): 295-298, 2017 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27908764
9.
Discovery of BMS-961955, an allosteric inhibitor of the hepatitis C virus NS5B polymerase.
Bioorg Med Chem Lett
; 27(15): 3294-3300, 2017 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28633899
10.
Phosphocholine conjugation: an unexpected in vivo conjugation pathway associated with hepatitis c ns5b inhibitors featuring a bicyclo[1.1.1]pentane.
Drug Metab Dispos
; 44(8): 1332-1340, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26961241
11.
Discovery and preclinical evaluation of potent, orally bioavailable, metabolically stable cyclopropylindolobenzazepine acylsulfonamides as thumb site 1 inhibitors of the hepatitis c virus NS5B RNA-dependent, RNA polymerase.
Bioorg Med Chem Lett
; 26(3): 936-940, 2016 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26747393
12.
Homology models of the HIV-1 attachment inhibitor BMS-626529 bound to gp120 suggest a unique mechanism of action.
Proteins
; 83(2): 331-50, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25401969
13.
Preclinical characterization of BMS-791325, an allosteric inhibitor of hepatitis C Virus NS5B polymerase.
Antimicrob Agents Chemother
; 58(6): 3485-95, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24733465
14.
Identification of a novel series of potent HCV NS5B Site I inhibitors.
Bioorg Med Chem Lett
; 24(8): 1993-7, 2014 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24656612
15.
Inhibitors of HIV-1 attachment. Part 9: an assessment of oral prodrug approaches to improve the plasma exposure of a tetrazole-containing derivative.
Bioorg Med Chem Lett
; 23(1): 209-12, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23200244
16.
Inhibitors of HIV-1 attachment. Part 10. The discovery and structure-activity relationships of 4-azaindole cores.
Bioorg Med Chem Lett
; 23(1): 213-7, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23200254
17.
Inhibitors of HIV-1 attachment. Part 11: the discovery and structure-activity relationships associated with 4,6-diazaindole cores.
Bioorg Med Chem Lett
; 23(1): 218-22, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23206859
18.
Inhibitors of HIV-1 attachment. Part 7: indole-7-carboxamides as potent and orally bioavailable antiviral agents.
Bioorg Med Chem Lett
; 23(1): 198-202, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23200252
19.
Inhibitors of HIV-1 attachment. Part 8: the effect of C7-heteroaryl substitution on the potency, and in vitro and in vivo profiles of indole-based inhibitors.
Bioorg Med Chem Lett
; 23(1): 203-8, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23200249
20.
Potent Long-Acting Inhibitors Targeting the HIV-1 Capsid Based on a Versatile Quinazolin-4-one Scaffold.
J Med Chem
; 66(3): 1941-1954, 2023 02 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36719971